As part of an international research team, scientists at Belgorod State University (NRU BelSU) near the Ukrainian border have identified the genetic prerequisites for intrauterine growth restriction. According to the authors of the study, the data obtained will make it possible to predict this dangerous pathology and take remedial measures.
The results of the study were published in European Journal of Obstetrics & Gynecology and Reproductive Biology.
Placental insufficiency leading to intrauterine growth restriction is a pregnancy complication, affecting up to 10 per cent of women, NRU BelSU researchers noted. This pathology is a serious perinatal mortality and morbidity factor, which leads to obesity, cardiovascular diseases and Type-II diabetes when the newborn grows up.
According to NRU BelSU scientists, it’s generally believed that heredity determined 40 per cent of the newborn’s physiological formation processes, and outward influences determine 60 per cent. At the same time, according to the researchers, the role of genetic factors has so far been understudied.
NRU BelSU Scientists have analysed the relationship of several gene polymorphisms with intrauterine growth restriction and assessed their regulatory potential. The study involved 196 pregnant women with placental insufficiency and 324 women with a physiologically healthy pregnancy.
Moreover, NRU BelSU scientists noted that these ESR1loci are associated with other female reproductive system pathologies: pre-eclampsia, miscarriage, infertility, and tumours.
According to the researchers, the study results should be used to form a risk group among pregnant women who need special prenatal support. Medical supervision, diet, using drug complexes and other measures will help reduce the risk of developing a dangerous pathology, the scientists pointed out.
The study involved specialists from Kursk State Medical University and Alfaisal University (Saudi Arabia). The experiment involved the patients of the Perinatal Centre at Saint Ioasaph Belgorod Regional Clinical Hospital. The research team now wants to continue studying the role of genetic factors in pregnancy pathologies development.
Sourse: sputniknews.com
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